Omalizumab for Asthma

Omalizumab (Xolair, Genentech) is a recombinant humanized IgG1 monoclonal anti-IgE antibody that binds to the IgE molecule at the same epitope on the Fc region that binds to FcεRI.11,12 This design means that omalizumab is not anaphylactogenic, since it cannot interact with IgE that is already bound to cell surfaces and thus cannot induce degranulation of mast cells or basophils.8,13 Instead, omalizumab binds to circulating IgE, regardless of allergen specificity, forming small, biologically inert IgE–anti-IgE complexes without activating the complement cascade.8,12,14 An 89 to 99 percent reduction in free serum IgE (i.e., IgE not bound to omalizumab) occurs soon after the administration of omalizumab, and low levels persist throughout treatment with appropriate doses.14,15 Proof-of-concept studies have shown that omalizumab reduces both early- and late-phase asthmatic responses after allergen inhalation challenge,16 has a marked effect on late-phase as compared with early-phase skin responses,17 decreases eosinophil numbers in sputum18 and submucosal bronchial specimens,18 and also down-regulates FcεRI on basophils,19 mast cells,20 and dendritic cells.21 A reduction in the expression of FcεRI on basophils and mast cells decreases the binding of circulating IgE, thus preventing the release of inflammatory mediators. A reduction in the expression of FcεRI on dendritic cells may decrease allergen processing and presentation.

Hayfever Symptoms And Remedies.

Hay fever or allergic rhinitis is an allergic inflammation where the individual nasal airways becomes blocked when dust, allergen or pollen grains attack the nasal path. Most of the time, people with weak immunity are more susceptible to pollenosis. When the pollens or dust goes into the the body, it triggers the production of antibodies.

These antibodies contain histamine is a nitrogen compound that regulates the physiological function and acts as neurotransmitter in the physiology. The pollenosis is classified in various categories such as tree pollen allergies, pollen allergies, animal allergies, dust mite allergies, perennial allergic rhinitis and seasonal allergic rhinitis.
Symptoms of Allergic Rhinitis

Eye Allergies

An eye allergy that affects the conjunctiva, a clear layer of skin overlying the eyes, is commonly referred to as allergic conjunctivitis.

Allergic conjunctivitis is divided into several major subtypes, but the most common subtypes are seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC). SAC and PAC are triggered by an immune reaction involving a sensitized individual and an allergen. Simply stated, this means that if you are allergic to a particular substance and then come into contact with it, you experience an allergic reaction (symptoms like itching and sneezing).

Although it frequently occurs, allergic conjunctivitis is most commonly seen in areas with high seasonal allergens.

Causes of Eye Allergies

Eye allergies often affect the conjunctiva, a clear layer of skin overlying the eyes. This clear layer of skin is the same type of skin that lines the inside surface of the nose. Because these two areas are so similar, the same allergens (substances that induce an allergic reaction) can trigger the same allergic response in both areas.

Asthma And Panic Attacks

Asthma and panic attacks often go hand in hand. Studies have shown that there is a strong relationship between the two and people having asthma are often more prone to panic attacks. The finding is significant in the sense that it could pave new ways for asthma treatment. According to these studies, a person with asthma is 4.5 times more likely to have panic attacks than those who do not have the disease. Vice versa, people who suffer panic attacks are more likely to develop asthma in course of time.

The problem here is that it is often difficult to distinguish between asthma and panic attacks. Panic attacks are not life-threatening, but asthma is. So, if a person has both, he or she should be extremely careful. It has been observed that an asthma attack can cause such anxiety that it may easily cause a panic attack, making the asthma attack even worse and forming a terrible cycle. In both asthma and panic attacks, the victim finds breathing difficult and loses the ability to think and remain calm.

WeatherMD Helps You Manage Environmental Triggers of Disease

AccuWeather is now offering an iPhone app that helps translate current and forecast conditions into medically relevant information. WeatherMD provides weather/health maps and charts that predict how conditions will influence people with a number of relevant ailments. Probably most useful for people with conditions like hay fever, asthma, and arthritis, it is also practical for anyone planning to exercise outdoors. The app costs $4 and currently only provides info for US locations. 

You'll appreciate accurate forecasts and current conditions that include wind speed and direction, sky conditions, as well as AccuWeather.com patented RealFeel temperature, Healthy Heart Exercise, and Running indices so you know how to plan and dress for your daily run or bike ride.